Plasma ascorbate and ceruloplasmin levels in Thai premature infants.
J Med Assoc Thai
; 88(2): 205-13, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-15962672
ABSTRACT
BACKGROUND:
Free radicals have been implicated in the pathogenesis of some complications among premature infants. Even though ascorbate is an important anti-oxidant in human plasma, it can also act as a pro-oxidant at high concentrations in the presence of metal ions, which causes oxidative damage in premature infants.OBJECTIVE:
To determine plasma ascorbate and ceruloplasmin levels in premature infants (and their mothers) and full-term infants and to compare between groups. MATERIAL ANDMETHOD:
Premature (n = 27) and full-term infants (n = 24) and the mothers of the premature infants (n = 13) admitted to Srinagarind Hospital, Khon Kaen University, Thailand, were enrolled in the study. Plasma ascorbate and ceruloplasmin levels were determined and compared among various clinical presentations.RESULTS:
Plasma ascorbate has negative correlation with gestational age of infants. Its level on day 1 of the premature infants was significantly higher than full-term group (52.62 vs 39.00 micromol/L) and then decline after birth. Premature infants receiving oxygen therapy had lower plasma ascorbate than premature infants without oxygen therapy (p = 0.017). Plasma ascorbate in premature infants who died was higher than in those that survived (p = 0.029). Premature infants with poor outcomes had a higher ratio of plasma ascorbate to ceruloplasmin than those with good outcomes (p < 0.05).CONCLUSION:
This study shows that high plasma ascorbate and low ceruloplasmin levels are associated with poor outcomes of premature infants; that is, ascorbate can act as either an anti-oxidant or a pro-oxidant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Ceruloplasmina
/
Recém-Nascido Prematuro
Limite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Med Assoc Thai
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Tailândia