Effect of IFN-alpha on CC1 4-induced fibrosis of the liver and immune status in mice of different age.
Bull Exp Biol Med
; 139(3): 324-7, 2005 Mar.
Article
em En, Ru
| MEDLINE
| ID: mdl-16027843
ABSTRACT
In young, adult, and old mice fibrosis was induced by administration of CC1(4) and treated with IFN-alpha; liver fibrosis was evaluated by morphometry of argyrophilic fibers, immune status by the splenocyte proliferative response. minimum immunosuppression and maximum antifibrotic effect were observed in young mice, while adult mice exhibited pronounced immunotoxicity and weak response to interferon therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Interferon-alfa
/
Cirrose Hepática Experimental
Limite:
Animals
Idioma:
En
/
Ru
Revista:
Bull Exp Biol Med
Ano de publicação:
2005
Tipo de documento:
Article