Nanoscale-controlled spacing provides DNA microarrays with the SNP discrimination efficiency in solution phase.
Langmuir
; 21(10): 4257-61, 2005 May 10.
Article
em En
| MEDLINE
| ID: mdl-16032830
ABSTRACT
We have prepared solid substrates modified with a cone-shaped dendron that generates mesospacing (3.2 nm on average) on the surface. This nanoscale-controlled surface provided an ideal DNA microarray in which each probe DNA strand was given ample space for the incoming target DNA, resulting in selectivity as high as that in solution (100 < 1). In addition, high hybridization yield confirms that DNA probes on the mesospaced surface are sterically unhindered for the hybridization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Análise de Sequência com Séries de Oligonucleotídeos
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Langmuir
Assunto da revista:
QUIMICA
Ano de publicação:
2005
Tipo de documento:
Article