Acute tryptophan depletion as a model of depressive relapse: behavioural specificity and ethical considerations.
Br J Psychiatry
; 187: 148-54, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16055826
ABSTRACT
BACKGROUND:
Acute tryptophan depletion transiently induces symptoms in those with remitted depression. The behavioural specificity is uncertain, however. Recently, symptom provocation studies have become controversial, particularly in the USA.AIMS:
To assess the specificity of acute tryptophan depletion. To investigate systematically the subjective experiences of those taking part in a symptom provocation study.METHOD:
Twenty individuals with remitted depression underwent acute tryptophan depletion in a double-blind, crossover trial. Psychiatric symptoms and self-schemata relevant to depression were assessed. The quality of the informed consent procedure and subjective experiences were also evaluated.RESULTS:
Acute tryptophan depletion induced a specific depressive response. The effects were more pronounced in females than in males. Participants were quite satisfied with the informed consent procedure. They had understood that this was a fundamental research project and personal benefits were not expected. However, some participants still found it a positive experience.CONCLUSIONS:
Acute tryptophan depletion is a suitable model of vulnerability to depression, from both a scientific and an ethical perspective.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triptofano
/
Transtorno Depressivo
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Aspecto:
Ethics
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Holanda