In vitro sensitized autologous tumorocidal lymphocytes to colonic adenocarcinoma.
Eur J Surg Oncol
; 18(3): 258-63, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1607038
ABSTRACT
We report a method of developing a population of tumorocidal lymphocytes by culturing peripheral blood mononuclear cells (PBMC) with live isogenic colorectal tumour cells in a mixed cell culture. When the proportion of PBMC to tumour cells is 1001, eradication of the tumour cell population results. The proportion of activated lymphocytes in culture increases with cytotoxic activity as demonstrated by the presence of the cytotoxic enzyme serine esterase in the lymphocyte granules.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Adenocarcinoma
/
Neoplasias do Colo
/
Citotoxicidade Imunológica
/
Esterases
Limite:
Humans
Idioma:
En
Revista:
Eur J Surg Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Reino Unido