[Isolated acquired factor VII deficiency in patient with severe head trauma: use of factor VII (factor VII-LFB]. / Déficit acquis et isolé en facteur VII contemporain d'un traumatisme crânien grave: utilisation du substitut de facteur VII (facteur VII-LFB).
Ann Fr Anesth Reanim
; 24(11-12): 1383-6, 2005.
Article
em Fr
| MEDLINE
| ID: mdl-16099130
ABSTRACT
We report a case of transient acquired and isolated factor VII deficiency associated with severe head trauma. A 16-year-old boy was involved in a motor vehicle accident. CT scan showed frontal brain contusion and a cerebral haematoma (5 cm). First prothrombine time (PT) was normal. Rapidly, a severe coagulopathy developed, unresponsiving to fresh frozen plasma and vitamin K. Haemostatic markers analysis showed an isolated deficiency of factor VII at 15%. No inhibitory activity against factor VII could be detected. We successfully treated the deficiency with intermittent intravenous human factor VII (factor VII-LFB) during 10 days. Factor VII return to normal at 84%. Physiopathological and therapeutic aspects of this rare pathology are presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
/
Fator VII
/
Traumatismos Craniocerebrais
Limite:
Adolescent
/
Humans
/
Male
Idioma:
Fr
Revista:
Ann Fr Anesth Reanim
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
França