In vitro sustained human transscleral drug delivery of fluorescein-labeled dexamethasone and methotrexate with fibrin sealant.
Curr Eye Res
; 30(8): 653-60, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16109645
ABSTRACT
PURPOSE:
To study the use of fibrin sealant as a drug delivery system for the sustained transscleral delivery of dexamethasone and methotrexate.METHODS:
Scleral sections excised from moist-chamber-stored human globes were mounted in a perfusion chamber. Dexamethasone-fluorescein or methotrexate-fluorescein in either fibrin sealant or balanced salt solution (BSS) was applied to the episcleral surface. BSS was perfused to the choroidal side, fluorescence was measured in perfusate fractions, and an apparent scleral permeability P(A) was calculated for each solute-vehicle combination.RESULTS:
P(A) for both compounds was significantly lower with fibrin sealant delivery compared to delivery in BSS (p < 0.001). However, the fibrin sealant vehicle provided a more sustained release of both drugs through 24 hr.CONCLUSIONS:
Incorporating dexamethasone and methotrexate into a fibrin sealant provided a more gradual drug delivery and a more uniform delivery compared to dissolving these drugs in BSS. Fibrin sealant could be useful for transscleral delivery for posterior segment disease.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esclera
/
Adesivos Teciduais
/
Dexametasona
/
Adesivo Tecidual de Fibrina
/
Metotrexato
/
Sistemas de Liberação de Medicamentos
/
Fluoresceínas
/
Glucocorticoides
Limite:
Humans
/
Middle aged
Idioma:
En
Revista:
Curr Eye Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Holanda