[Influence of ML-1 standardized mistletoe extract on the quality of life in head and neck cancer patients]. / Einfluss eines ML-1-normierten Mistelextraktes auf die Lebensqualität bei Patienten mit Kopf-Hals-Karzinomen.
HNO
; 54(4): 277-86, 2006 Apr.
Article
em De
| MEDLINE
| ID: mdl-16132877
ABSTRACT
BACKGROUND:
ML-1 standardized mistletoe extracts have been recommended for increasing the health-related quality of life in cancer patients. PATIENTS ANDMETHODS:
The EORTC questionnaire QLQ-C30((V2)) was given to a randomly chosen subgroup of 399 patients of a prospective, randomized, open, multi-center trial. A total of 200 patients from this trial were randomized for ML-1 treatment (1 ng/kg body weight ML-1 was injected subcutaneously twice weekly over a 60-week period. Treatment cycles of 12 weeks were followed by a break of 4 weeks (between weeks 12-16, 28-32, and 44-48)). The remaining 199 patients formed the control group.RESULTS:
Patients completed questionnaires before the start of their treatments at week 0 and continued until week 156. The compliance rate was high 3611 questionnaires were available, which equals a median of nine longitudinal measurements per patient between weeks 0 and 156. Analysis did not indicate any improvement in the quality of life for either group. A significant decrease in quality of life, however, was seen in patients undergoing radiotherapy. In these patients, the global state of health was reduced and four symptom scales were significantly worse.CONCLUSION:
Our results demonstrated no improvement in the quality of life in head and neck cancer patients when treated with ML-1 extract.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
/
Qualidade de Vida
/
Toxinas Biológicas
/
Neoplasias Otorrinolaringológicas
/
Extratos Vegetais
/
Preparações de Plantas
/
Fitoterapia
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Clinical_trials
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Observational_studies
/
Prognostic_studies
/
Qualitative_research
Aspecto:
Patient_preference
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
De
Revista:
HNO
Ano de publicação:
2006
Tipo de documento:
Article