Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions.
Org Lett
; 7(20): 4543-5, 2005 Sep 29.
Article
em En
| MEDLINE
| ID: mdl-16178579
ABSTRACT
[reaction see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 991) were obtained under the optimal conditions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prolina
/
Desenho de Fármacos
/
Aldeídos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China