Activity-mediated shift in reversal potential of GABA-ergic synaptic currents in immature neurons.
Brain Res Dev Brain Res
; 160(1): 78-84, 2005 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-16203042
ABSTRACT
Gamma-aminobutyric acid (GABA), which is inhibitory in the adult central nervous system, can be excitatory in the developing brain. The change from excitatory to inhibitory action of GABA during development is caused by a negative shift in its reversal potential. Here, we report a presynaptic activity-mediated negative shift in the reversal potential of the GABA-mediated synaptic currents in immature deep cerebellar nuclei neurons. This shift appears to be due to an increased expression and activation of the K+-Cl- co-transporter type 2 (KCC-2) through the activation of protein kinase A, protein synthesis and activation of protein phosphatases. Thus, maturation of the GABA response may rely on an activity-dependent up-regulation of KCC-2.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Transmissão Sináptica
/
Simportadores
/
Ácido gama-Aminobutírico
/
Inibição Neural
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Brain Res Dev Brain Res
Assunto da revista:
CEREBRO
/
NEUROLOGIA
Ano de publicação:
2005
Tipo de documento:
Article