Your browser doesn't support javascript.
loading
The Streptomyces lividans cytoplasmic signal recognition particle receptor FtsY is involved in protein secretion.
Palomino, Carmen; Mellado, Rafael P.
Afiliação
  • Palomino C; Centro Nacional de Biotecnología, Campus de la Universidad Autónoma, Cantoblanco, Madrid, Spain.
J Mol Microbiol Biotechnol ; 9(1): 57-62, 2005.
Article em En | MEDLINE | ID: mdl-16254447
The bacterial version of the mammalian signal recognition particle (SRP) and its receptor alpha-subunit (FtsY) is well conserved and essential to all known bacteria. In gram-negative bacteria, the SRP pathway mediates a co-translational targeting of most inner membrane proteins. Additionally, in Streptomyces lividans, a gram-positive bacterium, SRP also targets secretory proteins to the translocon. The role of S. lividans FtsY has been assessed in this work. Co-immunoprecipitation studies confirmed that FtsY is associated with the S. lividans SRP in the cytoplasm and that this complex also co-immunoprecipitated with pre-agarase, suggesting that the SRP receptor is involved in SRP-mediated targeting of secretory proteins in S. lividans. Furthermore, the SRP remains attached for the most part to the cellular membrane when the cleavage of pre-secretory proteins is severely reduced in a strain lacking the gene coding for the major type-I signal peptidase.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Receptores Citoplasmáticos e Nucleares / Transporte Proteico / Streptomyces lividans Idioma: En Revista: J Mol Microbiol Biotechnol Assunto da revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA / MICROBIOLOGIA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Espanha País de publicação: Suíça
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Receptores Citoplasmáticos e Nucleares / Transporte Proteico / Streptomyces lividans Idioma: En Revista: J Mol Microbiol Biotechnol Assunto da revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA / MICROBIOLOGIA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Espanha País de publicação: Suíça