Hepatocellular toxicosis associated with the alternate administration of carprofen and meloxicam in a siberian husky.
J Vet Med Sci
; 67(10): 1051-3, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16276063
ABSTRACT
A 4-year-old female Siberian Husky was diagnosed with pyogranulomatous steatitis at the site of a recurrence of left anal sac rupture (day 1). Carprofen and orbifloxacin were given for 13 days without improvement. A single dose of meloxicam was administered prior to surgical resection of the anal sac, and based on elevated liver enzyme activity, liver supportive therapy was initiated. The dog received carprofen and orbifloxacin orally on the evening of day 14. The dog became anorectic the following morning, and began vomiting. Despite supportive therapy, the dog was unresponsive to treatment and died on day 16. Postmortem examination revealed severe vacuolar change and acute necrosis of hepatocytes consistent with carprofen and meloxicam induced-toxicosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteatite
/
Tiazinas
/
Tiazóis
/
Carbazóis
/
Anti-Inflamatórios não Esteroides
/
Doenças do Cão
/
Doença Hepática Induzida por Substâncias e Drogas
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Vet Med Sci
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão