Cetuximab-induced acne.
Dermatology
; 211(4): 330-3, 2005.
Article
em En
| MEDLINE
| ID: mdl-16286741
ABSTRACT
BACKGROUND:
Cetuximab is a member of a new family of antineoplastic agents that inhibit epidermal growth factor receptor (EGFR). These molecules may induce acneiform eruptions. In this study, we aimed at evaluating (a) the characteristics of acne and (b) whether these acneiform eruptions could be improved by classical anti-acne treatments.METHODS:
All patients treated with cetuximab in a single institution from October 2003 to May 2004 were prospectively evaluated. The presence of acne, its severity, need for a treatment and response to this treatment were recorded.RESULTS:
13 patients were included 11 (85%) developed acneiform eruptions after a mean interval of 10 days. It was severe in 4/13 (31%). Comedones were never found and acne involved nonclassical sites in 3/11. Antibiotic treatment was given to 4 and local treatment to 2 patients it was always efficient.CONCLUSION:
Cetuximab-induced acne is frequent, differs from classical acne and may be treated effectively with classical modalities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxidermias
/
Acne Vulgar
/
Receptores ErbB
/
Anticorpos Monoclonais
/
Antineoplásicos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Aspecto:
Patient_preference
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Dermatology
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
França