Alcohol dehydrogenase (ADH). Influence of homo- and heterologous ADH administration on albino rats craving for alcohol and on ADH isozyme activity in the liver.

Ashmarin, I P; Danilova, R A; Pshezhetsky, A V; Fedorova, I M; Obukhova, M F; Sagimbaeva, Sh K

Ashmarin, I P; Danilova, R A; Pshezhetsky, A V; Fedorova, I M; Obukhova, M F; Sagimbaeva, Sh K.

Afiliação

Ashmarin IP; Department of Human and Animal Physiology, School of Biology, Moscow University, Russia.

FEBS Lett ; 306(1): 38-40, 1992 Jul 13.

Article em En | MEDLINE | ID: mdl-1628741

ABSTRACT

ABSTRACT

The effects of homo- and heterologous alcohol dehydrogenase (ADH) administration into albino rats were investigated. It was found that homologous ADH increases and heterologous ADH decreases the craving for ethanol. The latter effect was accompanied by the appearance of anti-ADH-3 antibodies and by a decrease in ADH-3 activity in the liver. Craving for alcohol decreased after both active and passive immunization against ADH.

Assuntos

Álcool Desidrogenase/farmacologia; Consumo de Bebidas Alcoólicas; Alcoolismo/metabolismo; Isoenzimas/metabolismo; Fígado/enzimologia; Álcool Desidrogenase/administração & dosagem; Álcool Desidrogenase/imunologia; Álcool Desidrogenase/metabolismo; Animais; Comportamento Aditivo; Ensaio de Imunoadsorção Enzimática; Cavalos; Imunização Passiva; Ratos; Vacinação

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcool Desidrogenase / Consumo de Bebidas Alcoólicas / Alcoolismo / Isoenzimas / Fígado Limite: Animals Idioma: En Revista: FEBS Lett Ano de publicação: 1992 Tipo de documento: Article País de afiliação: Federação Russa

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