Control of oral biofilm formation by an antimicrobial decapeptide.
J Dent Res
; 84(12): 1172-7, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16304449
ABSTRACT
Oral biofilms are mixed-species microbial communities, and their uncontrolled outgrowth can express as oral diseases. Antimicrobial peptides represent alternative classes of antimicrobials that exhibit selectivity for prokaryotes. We wanted to test the effect of a synthetic decapeptide antimicrobial, KSL, on the development of oral biofilms formed by isolated human salivary bacteria. We used differential interference contrast microscopy, coupled with a dual-flow cell system, to determine the effect of KSL on oral biofilm development. We used reductions of viable counts and confocal microscopy to assess the bactericidal activity of KSL on mature oral biofilms. KSL effectively blocked biofilm development. A significant effect on the viability of mature biofilms was observed when KSL was used in the presence of a surface-active agent, or after biofilms were mechanically disrupted. This study shows that KSL may be a useful adjunct for conventional oral hygiene to prevent plaque-mediated dental diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Biofilmes
/
Depsipeptídeos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
J Dent Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos