Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.
J Neuroimmunol
; 172(1-2): 9-17, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16325924
ABSTRACT
A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the disease remain to be elucidated. The current study examined the effects of a single dose of morphine prior to infection with HSV-1 on the development of HSVE in BALB/cByJ mice. Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Herpesvirus Humano 1
/
Encefalite
/
Morfina
/
Entorpecentes
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos