Expression and functional analysis of fibulin-1 (Fbln1) during normal and abnormal placental development of the mouse.
Placenta
; 27(9-10): 1014-21, 2006.
Article
em En
| MEDLINE
| ID: mdl-16338003
ABSTRACT
The extracellular matrix protein fibulin-1 (FBLN1) is an important component of blood vessel walls, as shown by the lethality of mice with homozygous targeted deletion of the Fbln1 gene. Here, we show that a murine placental overgrowth phenotype is associated with elevated Fbln1 transcript levels, suggesting that the gene and its product have a functional role in placentation. Fbln1 exhibits a specific expression pattern in the mouse placenta. Transcripts could not be detected prior to day 12. In subsequent stages, Fbln1 was expressed strongly in the spongiotrophoblast. Other sites of expression were endothelia of large fetal blood vessels, a tissue type reported to not express this gene. In addition, a subset of giant cells expressed the gene. This giant cell specific expression was strongly increased in hyperplastic placentas. Analysis of the placentation in fibulin null mice did not show any abnormality. Attempts to rescue the placental phenotypes of a congenic model of interspecies hybrid placental dysplasia (IHPD) by normalizing expression of Fbln1 proved that Fbln1 alone is not the key cause of phenotypes in these models of placental hyperplasia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Placentação
/
Proteínas de Ligação ao Cálcio
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Placenta
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Suécia