APOA5 variant Ser19Trp influences a decrease of the total cholesterol in a male 8 year cohort.
Clin Biochem
; 39(2): 133-6, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16386723
ABSTRACT
OBJECTIVES:
To evaluate whether the relationship between dietary composition and plasma lipid levels is genetically determined. DESIGN ANDMETHODS:
We have evaluated the influence of common apolipoprotein A5 (APOA5) variants (T-1131 > C, Ser19 > Trp and Val153 > Met) on plasma lipid concentrations in 117 males for whom dietary composition markedly changed and total cholesterol decreased (from 6.21 +/- 1.31 mmol/L in 1988 to 5.43 +/- 1.06 mmol/L in 1996) over an 8 year follow-up study.RESULTS:
APOA5 T-1131 > C and Val153 > Met variants did not influence the change in lipid measures over time. In Ser/Ser19 homozygotes, the plasma cholesterol was relatively stable over the years (6.1 +/- 1.2 mmol/L in 1988 and 5.6 +/- 1.0 mmol/L in 1996, -8%, P < 0.01). In contrast, in the Trp19 carriers, the decrease of the plasma cholesterol was more than 20% (6.5 +/- 1.6 mmol/L in 1988 and 5.1 +/- 1.0 mmol/L in 1996) (P < 0.001). The difference of the changes is significant (8% vs. 20%, P < 0.005). Changes in other analyzed lipid parameters have not been significantly associated with APOA5 variants.CONCLUSIONS:
Ser19 > Trp variant in the APOA5 gene may play an important role in an individual's sensitivity to dietary composition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas
/
Colesterol
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
República Tcheca