Smoothened, thickveins and the genetic control of cell cycle and cell fate in the developing Drosophila eye.
Mech Dev
; 123(2): 151-65, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16412615
ABSTRACT
The Hedgehog and Decapentaplegic pathways have several well-characterized functions in the developing Drosophila compound eye, including initiation and progression of the morphogenetic furrow. Other functions involve control of cell cycle and cell survival as well as cell type specification. Here we have used the mosaic clone analysis of null mutations of the smoothened and thickveins genes (which encode the receptors for these two signals) both alone and in combination, to study cell cycle and cell fate in the developing eye. We conclude that both pathways have several, but differing roles in furrow induction and cell fate and survival, but that neither directly affects cell type specification.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Proteínas Serina-Treonina Quinases
/
Receptores de Superfície Celular
/
Proteínas de Drosophila
/
Receptores Acoplados a Proteínas G
/
Drosophila
/
Olho
/
Morfogênese
Limite:
Animals
Idioma:
En
Revista:
Mech Dev
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos