Identification of c-Kit gene mutations in patients with polycythemia vera.
Leuk Res
; 30(10): 1325-6, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16460801
ABSTRACT
Imatinib mesylate has recently been reported to have clinical activity in the treatment of polycythemia vera (PV), suggesting the involvement of one of the kinases targeted by this inhibitor, including c-Kit and PDGFR. Activating c-Kit mutations have been identified in patients with mastocytosis and other myeloid disorders such as acute myeloid leukemia. Thus, we wanted to analyze the presence of mutations of c-Kit in polycythemia vera patients. We found that 7 out of 20 patients carried missense mutations in the c-Kit gene whereas no sequence variation was detected in 15 healthy controls.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
/
Proteínas Proto-Oncogênicas c-kit
/
Mutação de Sentido Incorreto
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2006
Tipo de documento:
Article