Drug resistance among smear-positive tuberculosis patients in Ho Chi Minh City, Vietnam.
Int J Tuberc Lung Dis
; 10(2): 160-6, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16499254
ABSTRACT
OBJECTIVES:
To assess the pattern of drug resistance among smear-positive tuberculosis (TB) patients in an inner city area in Vietnam.METHODS:
A random sample of patients diagnosed by the national TB programme (NTP) were offered HIV testing and submitted sputum for Mycobacterium tuberculosis drug sensitivity testing.RESULTS:
Of 1433 isolates from new patients, 360 (25%) were resistant to isoniazid (INH), 57 (4.0%) to rifampicin (RMP), 421 (29%) to streptomycin (SM) and 28 (2.0%) to ethambutol. Among 401 previously treated patients, this was 218 (54%), 109 (27%), 217 (54%) and 26 (7%), respectively. Multidrug resistance (MDR) was observed in 55 (3.8%) new and 102 (25%) previously treated patients. RMP resistance was strongly associated with resistance to INH (OR 46) and INH plus SM (OR 91, P = 0.004). Prevalence of drug resistance tended to decrease with age. Neither any resistance nor MDR was significantly associated with HIV infection.CONCLUSIONS:
In this inner city area, levels of drug resistance, in particular of MDR among previously treated patients, are high. This may be related to the use of NTP regimens in the context of highly prevalent combined SM and INH resistance which may favour acquisition of RMP resistance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
População Urbana
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Farmacorresistência Bacteriana
/
Antibióticos Antituberculose
/
Mycobacterium tuberculosis
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Vietnã