Noncompetitive inhibition of inositol monophosphatase by K-76 monocarboxylic acid.
Mol Pharmacol
; 40(1): 107-11, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1649963
K-76COONa, a fungal product that was previously isolated for its inhibition of complement activation, was found to inhibit myo-inositol monophosphatase activity. K-76COONa was slightly more potent than lithium, with a Ki of approximately 0.5 mM. Kinetic analyses with D-myo-inositol 1-phosphate as the substrate showed that myo-inositol monophosphatase inhibition by K-76COONa was noncompetitive relative to substrate but competitive with activation by magnesium. Higher concentrations of K-76COONa were necessary to inhibit myo-[3H]inositol 1,4-bisphosphate hydrolysis by inositol 1,4-bisphosphate/inositol 1,3,4-trisphosphate 1-phosphatase (IC50 = approximately 7.5 mM). K-76COONa may be useful for further investigation of the mechanism of myo-inositol monophosphatase and for determination of whether inhibition of this enzyme plays a role in the therapeutic effectiveness of lithium in treatment of affective disorders.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Monoéster Fosfórico Hidrolases
Limite:
Animals
Idioma:
En
Revista:
Mol Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article
País de publicação:
Estados Unidos