Effects of a red clover extract (MF11RCE) on endometrium and sex hormones in postmenopausal women.
Maturitas
; 55(1): 76-81, 2006 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-16513301
ABSTRACT
OBJECTIVE:
To evaluate the effects of a non-prescription red clover extract (MF11 RCE, Melbrosin International, Vienna, Austria) on selected sex hormones and endometrium in postmenopausal women. PATIENTS ANDMETHODS:
One-hundred and nine postmenopausal women with an age > or =40 years were randomly assigned to one of two groups either two capsules of MF11RCE (80mg isoflavone) per day for a 90 day period, or placebo of equal design. After a 7 day washout period, medication was crossed-over for another 90 days.RESULTS:
Combined evaluation demonstrated that supplementation with MF11RCE (verum), in contrast to placebo, significantly increased plasma testosterone levels and decreased endometrial thickness.CONCLUSION:
MF11RCE exerts a moderate effect on testosterone levels in postmenopausal women, while estradiol levels remained unchanged. The observed reduction of endometrial thickness provides further support for a safe role for isoflavones in terms of endometrial hyperplasia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios Esteroides Gonadais
/
Extratos Vegetais
/
Pós-Menopausa
/
Trifolium
/
Endométrio
/
Isoflavonas
/
Fitoterapia
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Maturitas
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Áustria
País de publicação:
IE
/
IRELAND
/
IRLANDA