The story of PON1: how an organophosphate-hydrolysing enzyme is becoming a player in cardiovascular medicine.
Neth J Med
; 64(2): 34-8, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16517986
ABSTRACT
Since the discovery of human serum paraoxonase (PON1), the enzyme has been the subject of various fields of research. Initially, PON1 was identified as an enzyme capable of hydrolysing organophosphate compounds, but there is a growing body of evidence that PON1 plays a role in lipid metabolism and the onset of cardiovascular disease. Still, the precise mechanism by which PON1 functions in vivo remains to be clarified. Here we will briefly review developments in the field of PON1 research which merit further attention.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Arteriosclerose
/
Doenças Cardiovasculares
/
Arildialquilfosfatase
Limite:
Humans
Idioma:
En
Revista:
Neth J Med
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Holanda