[Intraoperative intact parathyroid hormone determination as a predictive factor of hyperparathyroidism resolution]. / La determinación peroperatoria de PTHi como factor predictivo de curación en el hiperparatiroidismo.
Cir Esp
; 79(2): 114-9, 2006 Feb.
Article
em Es
| MEDLINE
| ID: mdl-16539950
ABSTRACT
INTRODUCTION:
The objectives of this study were a) to evaluate the effectiveness of intraoperative intact parathyroid hormone (PTHi) determination as a marker of hyperparathyroidism resolution; b) to establish the minimum number of blood samples required; and c) to determine whether cervical manipulation increases baseline PTHi levels. PATIENTS ANDMETHOD:
We performed a prospective study in 45 patients. Three intraoperative blood PTHi determinations were performed at baseline and at 10 and 25 minutes after excising the lesion. To analyze the effects of cervical manipulation, in 19 patients, 2 further determinations were made after 2 minutes of massage on both sides of the neck. A decrease of > 50% in PTHi values between postexeresis samples and the baseline sample (gradient > 50%) was used as diagnostic and therapeutic criteria and normalization of calcemia was used as a criteria for complete resolution.RESULTS:
Whenever the lesion causing hyperparathyroidism was extirpated, PTHi levels decreased at 10 and 25 minutes after exeresis. This decrease was predictive of complete resolution when the gradient was > 50. Cervical manipulation (massage) did not increase PTHi values. In patients with complete resolution, blood calcium levels also returned to normal.CONCLUSIONS:
1. Intraoperative PTHi determination with a gradient > 50 is an excellent prognostic marker of resolution. 2. Only 2 PTHi samples are required one at baseline and another at 10 minutes after exeresis. 3. Preoperative cervical manipulation does not increase PTHi values.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Hiperparatireoidismo
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Cir Esp
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
ES
/
ESPANHA
/
ESPAÑA
/
SPAIN