A short report on highlights of worldwide development of RIX4414: a Singaporean experience.
Vaccine
; 24(18): 3782-3, 2006 May 01.
Article
em En
| MEDLINE
| ID: mdl-16600443
ABSTRACT
In Singapore, we conducted a phase II randomized, double-blind, placebo-controlled dose ranging study using an attenuated human rotavirus vaccine, RIX4414. Altogether, 2464 healthy infants were recruited. Two oral doses of vaccine at 104.7, 105.2 or 106.1 ffu or placebo were administered with routine immunizations at 3 and 4 months of age. Seroconversion and 'vaccine take' in the vaccine groups 1-month post dose 2 varied from 76 to 91% and 98 to 100% respectively. Vaccine was well tolerated and did not interfere with response of concomitantly administered vaccines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Atenuadas
/
Vacinas contra Rotavirus
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Infant
País/Região como assunto:
Asia
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Singapura