[Procalcitonin for the diagnosis of neonatal sepsis of vertical transmission]. / Procalcitonina para el diagnóstico de sepsis neonatal de transmisión vertical.
An Pediatr (Barc)
; 64(4): 341-8, 2006 Apr.
Article
em Es
| MEDLINE
| ID: mdl-16606571
ABSTRACT
OBJECTIVE:
To evaluate procalcitonin (PCT) as a diagnostic marker of neonatal sepsis of vertical transmission and to compare the results of PCT with those of the most widely used laboratory tests for sepsis. PATIENTS ANDMETHODS:
A prospective study was conducted in 136 blood samples from 69 newborn infants admitted to a neonatal department. PCT, C-reactive protein (CRP), leukocyte count, and the immature-to-total neutrophil ratio (I/T ratio) were measured. The PCT reference range of controls from 0 to 72 hours of life was constructed, and the diagnostic efficiency of the tests was calculated, with their 95 % confidence intervals (95 % CI).RESULTS:
This study included 35 controls, 24 neonates with noninfectious disorders, and 10 neonates with sepsis (5 with culture-proven sepsis). PCT, CRP, and the I/T ratio discriminated septic from nonseptic patients. Their areas under the ROC curve were 0.696 (p = 0.009), 0.735 (p = 0.002), and 0.703 (p = 0.006), respectively, with no statistically significant differences. The accuracy of PCT, CRP, and leukocyte count improved after 24 hours of life with areas under the ROC curve of 0.813 (p = 0.007), 0.826 (p = 0.005), and 0.841 (p = 0.003), respectively. Overall, PCT detected vertically transmitted sepsis with a sensitivity of 68.4 % (95 % CI 46.0 %-84.6 %), specificity of 82.4 % (95 % CI 72.2 %-89.4 %), positive likelihood ratio of 3.89 (95 % CI 2.18 %-6.96 %), and negative likelihood ratio of 0.38 (95 % CI 0.19 %-0.76 %), similar to those of CRP.CONCLUSIONS:
PCT may be a useful marker for the diagnosis of vertically transmitted sepsis. Studies with larger sample sizes are required to establish the accuracy of PCT.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Calcitonina
/
Sepse
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
/
Newborn
Idioma:
Es
Revista:
An Pediatr (Barc)
Assunto da revista:
PEDIATRIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha