Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts.
J Nutr
; 136(5): 1300-4, 2006 May.
Article
em En
| MEDLINE
| ID: mdl-16614420
ABSTRACT
The mango, Mangifera indica L., is a fruit with high levels of phytochemicals, suggesting that it might have chemopreventative properties. In this study, whole mango juice and juice extracts were screened for antioxidant and anticancer activity. Antioxidant activity of the mango juice and juice extracts was measured by 3 standard in vitro methods. The results of the 3 methods were in general agreement, although different radicals were measured in each. Anticancer activity was measured by examining the effect on cell cycle kinetics and the ability to inhibit chemically induced neoplastic transformation of mammalian cell lines. Incubation of HL-60 cells with whole mango juice and mango juice fractions resulted in an inhibition of the cell cycle in the G(0)/G(1) phase. A fraction of the eluted mango juice with low peroxyl radical scavenging ability was most effective in arresting cells in the G(0)/G(1) phase. Whole mango juice was effective in reducing the number of transformed foci in the neoplastic transformation assay in a dose-dependent manner. These techniques provide valuable screening tools for health benefits derived from mango phytochemicals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bebidas
/
Extratos Vegetais
/
Ciclo Celular
/
Transformação Celular Neoplásica
/
Mangifera
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Nutr
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos