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A morphometric study of lung maturation in the adrenocorticotrophin-infused fetal lamb.
Kendall, J Z; Rivera-Alcina, M E; Plopper, C G; Weir, A J; Randall, G C; Saldana-Gautier, L.
Afiliação
  • Kendall JZ; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston.
Biol Neonate ; 60(3-4): 258-72, 1991.
Article em En | MEDLINE | ID: mdl-1665709
Adrenocorticotrophin (ACTH) effects on lung development were studied in sheep. ACTH was infused into 10 fetal lambs at 129 days of gestation at a rate of 29, 110 or 250 micrograms/day for 72 h, a time course which was independent of the mechanical and hormonal forces associated with labor. Lungs were compared with those of normal fetuses at term (day 147). ACTH accelerates maturation of components of lung structure toward term values. Different components of cytodifferentiation of the type II alveolar cell showed different levels of sensitivity. The degree of acceleration, not the nature of the changes, was influenced by dose.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Adrenocorticotrópico / Pulmão Limite: Animals / Pregnancy Idioma: En Revista: Biol Neonate Ano de publicação: 1991 Tipo de documento: Article País de publicação: Suíça
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Adrenocorticotrópico / Pulmão Limite: Animals / Pregnancy Idioma: En Revista: Biol Neonate Ano de publicação: 1991 Tipo de documento: Article País de publicação: Suíça