Catecholamine-induced cardiomyopathy in multiple endocrine neoplasia. A histologic, ultrastructural, and biochemical study.
Chest
; 99(2): 382-5, 1991 Feb.
Article
em En
| MEDLINE
| ID: mdl-1671211
ABSTRACT
A catecholamine-induced dilated cardiomyopathy is reported in a patient with multiple endocrine neoplasia, type 3. A histologic and ultrastructural study has been undertaken in cardiac biopsy samples, together with determination of myocardial Ca++ and cellular membrane fatty acids. Contraction band necrosis of cardiocytes with supercontraction of sarcomeres progressing to myofibrolysis and increased levels of myocardial Ca++ have been found as morphologic and biochemical abnormalities, respectively. No lipoperoxidation of cellular membranes or an alpha-adrenergic mediated reduction of coronary supply could be recognized in the study. We indicate a receptor-mediated intracellular Ca++ overload as the main abnormality responsible for myocardial impairment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Feocromocitoma
/
Neoplasia Endócrina Múltipla
/
Cardiomiopatia Dilatada
/
Catecolaminas
/
Neoplasias das Glândulas Suprarrenais
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Chest
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Itália