A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases.
Hum Genet
; 86(4): 363-4, 1991 Feb.
Article
em En
| MEDLINE
| ID: mdl-1671848
ABSTRACT
A diallelic restriction fragment length polymorphism of the CD3-epsilon (epsilon) gene, which encodes for an invariant component of the human T-lymphocyte receptor, is observed when using genomic DNA TaqI digests probed with a CD3-epsilon chain cDNA probe. This combination shows two alleles of 9.1 kb and 8.4 kb with a frequency of 0.66 and 0.34, respectively, in the Spanish population. None of these alleles is associated with susceptibility to juvenile rheumatoid arthritis (JRA) or insulin-dependent diabetes mellitus (IDDM).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Polimorfismo de Fragmento de Restrição
/
Receptores de Antígenos de Linfócitos T
/
Antígenos de Diferenciação de Linfócitos T
/
Antígenos CD
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hum Genet
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Espanha