['Migraine and a hole in the heart': causal relationship between migraine and patent foramen ovale not established]. / 'Migraine en een gaatje in het hart': oorzakelijk verband tussen migraine en foramen ovale persistens niet aangetoond.

ABSTRACT

The relationship between patent foramen ovale (PFO) and migraine is controversial. A common genetic background seems possible, but there is no evidence for a causal relationship. Despite the lack of evidence, PFO closure is recommended in many countries as a remedy for migraine. At present, PFO closure for migraine should only be carried out under strictly controlled clinical trial conditions.