[Changes of alpha1-adrenergic and muscarinic cholinergic responses of arterial blood pressure in the rabbit during adaptation to cold].
Ross Fiziol Zh Im I M Sechenova
; 92(3): 308-17, 2006 Mar.
Article
em Ru
| MEDLINE
| ID: mdl-16739640
ABSTRACT
Changes in major parameters of alpha1-adrenergic and muscarinic cholinergic responses of arterial blood pressure (EC50 and P(m)) were studied in rabbits adapted to cold for 1-30 days (daily cold exposures for 6 hours at -10 degrees C). It was shown that responses to noradrenaline, adrenaline (agonists of alpha1-adrenoceptors) and acetylcholine (agonist of muscarinic cholinoreceptors) could be expressed by equation p = (Pm- A(n))/(EC50(n) + A(n)) with n = 1. Adaptation to cold induced radically different changes in the major parameters of adrenergic and cholinergic responses. In the noradrenergic responses, the parameters EC50 and Pm gradually decreased within 1-30 days of adaptation. In the adrenaline responses, Pm increased from 1 to 30 days of adaptation, EC50 decreased to 10 day and increased on the 30th day. In the muscarinic cholinergic response, the Pm value decreased from 1 and 10 days but returned to control values on the 30th day. IC5O did not differ from the control 1 day, decreased to 10 days and increased on the 30th day.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Adaptação Fisiológica
/
Receptores Muscarínicos
/
Temperatura Baixa
/
Receptores Adrenérgicos alfa 1
Limite:
Animals
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article