Sokodosides, steroid glycosides with an isopropyl side chain, from the marine sponge Erylus placenta.
J Org Chem
; 71(13): 4884-8, 2006 Jun 23.
Article
em En
| MEDLINE
| ID: mdl-16776517
ABSTRACT
Two novel steroid glycosides, sokodosides A and B (1 and 2, respectively), were isolated from the marine sponge Erylus placenta as growth-inhibitory principles against several strains of yeast and a cancer cell line. Sokodosides possess the novel carbon skeleton as characterized by the presence of a combination of isopropyl side chain and the 4,4-dimethyl steroid nucleus. Sokodoside B has another unique characteristic in the presence of delta(8,14,16) unsaturation. The structures of sokodosides were determined by analysis of spectral data and chemical degradation. The absolute stereochemistry of sokodoside A (1) was determined by the application of the modified Mosher analysis to the aglycon obtained by acid hydrolysis, whereas the absolute stereochemistry of the monosaccharide units in 1 and 2 was determined by chiral GC analyses of the acid hydrolysates.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Esteroides
/
Glicosídeos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Japão