Effects of essential fatty acid contents of lipid emulsions on erythrocyte polyunsaturated fatty acid composition in patients on long-term parenteral nutrition.
Clin Nutr
; 11(5): 262-8, 1992 Oct.
Article
em En
| MEDLINE
| ID: mdl-16840007
ABSTRACT
The effect of the long-term intravenous infusion of 2 lipid emulsions, differing in essential fatty acid (EFA) content, on fatty acid pattern of red blood cell (RBC) was investigated in 5 patients with inflammatory bowel disease. They were randomly assigned to receive daily intravenous infusion of either a soybean emulsion or a mixed medium-chain triacyl-glycerols (MCT) soybean emulsion, followed by the other, each for a period of 3 months. The soybean emulsion contained exclusively long-chain triacylglycerols (LCT) with 54% of C182n-6 and 6% of C183n-3. The mixed emulsion consisted of a 5050 (ww) mixture of soybean LCT and MCT, providing half the amount of the same EFA compared to LCT emulsion. The same phospholipid emulsifier was used in both preparations. Infusion of LCT for a 3 month period modified RBC fatty acid pattern as follows 182n-6 increased, 204n-6 decreased as well as n-6n-3 ratio. By contrast, infusion of MCT/LCT did not alter RBC fatty acids, and even tended to correct a pattern altered by the previous LCT infusion. The study demonstrates that soybean LCT provides an excess of C18 2n-6 which affects the balance between RBC fatty acids in adult patients. Decreasing the intake of C182n-6 and C18 3n-3, by using a mixed MCT/LCT emulsion, appears more appropriate for keeping a balanced pattern.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Clin Nutr
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Bélgica