Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease.
J Physiol Pharmacol
; 57(2): 291-300, 2006 Jun.
Article
em En
| MEDLINE
| ID: mdl-16845232
ABSTRACT
Gastrointestinal dysmotility in Parkinson's disease (PD) has been attributed in part to peripheral neurotoxine action. Our purpose was the evaluation of the salsolinol effect on intramuscular interstitial cells of Cajal (ICC), duodenal myoelectrical activity (DMA) and vagal afferent activity (VAA) in rats with experimental PD. Twenty rats were divided into 2 equal groups. Experimental PD was produced in one group by 3 weeks of the intraperitoneal salsolinol injections (50 mg/kg/day), whereas the 2-nd group served as control. DMA and VAA were recorded in both groups during fasting and stepwise--gastric distension (GD) of 10 ml. Subsequently fragments of duodenum were removed and intramuscular ICC were assessed as c-Kit antigen percentage in the duodenal muscular zone. Analyses of the fasting DMA and VAA recordings didn't reveal differences between the compared groups. During GD increase of DMA dominant frequency (p=0.04) and VAA frequency (p<0.01) was observed in the controls whereas in the salsolinol group both parameters remained unchanged. Image analysis of duodenum revealed decreased c-Kit expression in the salsolinol-injected animals (p=0.05). The results of our study may suggest the direct effect of salsolinol on both ICC and neuronal pathways of gastro-duodenal reflexes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trânsito Gastrointestinal
/
Complexo Mioelétrico Migratório
/
Transtornos Parkinsonianos
/
Duodeno
/
Isoquinolinas
Limite:
Animals
Idioma:
En
Revista:
J Physiol Pharmacol
Assunto da revista:
FARMACOLOGIA
/
FISIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Polônia