Right occipital cortex suppresses male rat testosterone secretion by a pituitary-independent mechanism.
Neuro Endocrinol Lett
; 27(4): 501-5, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16891994
ABSTRACT
OBJECTIVES:
In addition to being regulated by the hypothalamo-hypophyseal system, testosterone (T) secretion is influenced by a number of less understood mechanisms. The aim of the present study was to examine whether defined areas of the right cerebral cortex could modulate T production.METHODS:
In adult male Wistar rats right frontal or occipital decortication, anterior or posterior callosotomy and corresponding sham-operations were performed. After 7-day survival time, T secretion in vitro, serum T and LH concentrations were measured by RIA.RESULTS:
Right occipital decortication and posterior callosotomy resulted in an increase in T secretion in vitro when compared to the corresponding sham-operated controls. In contrast, right frontal decortication or anterior callosotomy did not interfere with steroidogenesis. Serum LH concentration was not altered by any interventions.CONCLUSION:
The right occipital but not the right frontal cortex is involved in the control of T secretion. The caudal part of the corpus callosum accommodating the fibers originating from the occipital cortex might have a similar function. The fact that LH remained unchanged in all experimental groups suggests that the right occipital cortex and the caudal part of the corpus callosum influence testicular steroidogenesis by a pituitary-independent mechanism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adeno-Hipófise
/
Testosterona
/
Lateralidade Funcional
/
Lobo Occipital
Limite:
Animals
Idioma:
En
Revista:
Neuro Endocrinol Lett
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália