Selective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated rats.
FEBS Lett
; 580(20): 4889-94, 2006 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-16919274
ABSTRACT
A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gorduras na Dieta
/
Transdução de Sinais
/
Tecido Adiposo
/
Proteínas do Citoesqueleto
/
Proteína Oncogênica v-cbl
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil