Safety, feasibility, and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulation.
Stroke
; 37(10): 2562-6, 2006 Oct.
Article
em En
| MEDLINE
| ID: mdl-16960090
ABSTRACT
BACKGROUND AND PURPOSE:
The use of bare metal stents to treat symptomatic intracranial stenosis may be associated with significant restenosis rates. The advent of drug-eluting stents (DESs) in the coronary circulation has resulted in a reduction of restenosis rates. We report our technical success rate and short-term restenosis rates after stenting with DESs in the intracranial and extracranial circulation.METHODS:
This study was a retrospective review of the period between April 1, 2004, and April 15, 2006, of 59 patients with 62 symptomatic intracranial or extracranial atherosclerotic lesions at 2 medical centers (University of Pittsburgh and Borgess Medical Center).RESULTS:
The mean age of our cohort was 61+/-12 years. The location of the 62 lesions was as follows extracranial vertebral artery 31 (50%), intracranial vertebral artery or basilar artery 18 (29%), extracranial internal carotid artery (ICA) near the petrous bone 5 (8%), and intracranial ICA 8 (13%). There were 2 (3%) periprocedural complications 1 non-flow-limiting dissection and 1 disabling stroke. Fifty vessels were available for follow-up angiography or computed tomography angiography at a median time of 4.0+/-2 months. A total of 2 of 36 extracranial stents (7%) and 1 of 26 intracranial stents (5%) were found to have restenosis > or = 50% at follow-up.CONCLUSIONS:
This report demonstrates that DES delivery in the intracranial and extracranial circulation is technically feasible. A small percentage of patients developed short-term in-stent restenosis. Longer-term follow-up is required in the setting of a prospective study to determine the late restenosis rates for DESs in comparison with bare metal stents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Vertebrobasilar
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Artéria Carótida Externa
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Artéria Carótida Interna
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Stents
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Estenose das Carótidas
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Paclitaxel
/
Sirolimo
Tipo de estudo:
Etiology_studies
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Evaluation_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Stroke
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos