What clinicians need to know about antioestrogen resistance in breast cancer therapy.
Eur J Cancer
; 42(16): 2692-705, 2006 Nov.
Article
em En
| MEDLINE
| ID: mdl-16963260
ABSTRACT
Tamoxifen is the drug most used for early breast cancer treatment in oestrogen receptor (ER) positive patients. Unfortunately, despite high ER tumour levels in a tumour, resistance to endocrine therapy, either de novo or acquired after prolonged treatment, can occur. In this review, we will try to summarise the postulated mechanisms of hormonal-resistance, namely, the role of co-regulators and the crosstalk between the HER-2, IGF-IR, Cox-2 and ER pathways. Other predictive markers of tamoxifen-resistance/response, such as cyclin E and UPA/PAI-1, are also discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Resistencia a Medicamentos Antineoplásicos
/
Antagonistas de Estrogênios
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Cancer
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Bélgica