[Study on repair capacity of DNA damage associated with chronic benzene poisoning].
Wei Sheng Yan Jiu
; 35(4): 423-5, 2006 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-16986514
ABSTRACT
OBJECTIVE:
To explore the repair capacity of DNA damage associated with chronic benzene poisonings.METHODS:
63 workers suffered from chronic benzene poisonings and 45 workers exposed to benzene, who were engaged in the same job title, were investigated. Comet assay and cytokinesis-block micronucleus (CBMN) detection were used to evaluate gamma-radiation-induced DNA and chromosomal damage and repair capacity in peripheral blood lymphocyte.RESULTS:
The comet tail length difference of the benzene poisoning group (4.64 +/- 1.57 microm) was significantly higher than that of the control group (3.77 +/- 1.30 microm) (P = 0.0029). There was no significant difference of the 3AB index between the poisoning group and the control group. The relative risk of benzene poisoning in the subject with comet tail length difference > 3.81 was significantly higher than that in the subject with comet tail length difference < or = 3.81 microm (OR = 2.490, 95% CI1.068 - 5.806, P = 0.0346). The relative risk increased along with the comet tail length difference, and the trend was significant (P = 0.0024). There was no significant difference between the relative risk of benzene poisoning in the subject with 3AB index < 0.20 and that in the subject with 3AB index > or = 0.20.CONCLUSION:
DNA repair capacity on DNA-strand level might tightly associate with chronic benzene poisoning. The DNA repair capacity on DNA-strand level would be worse, and the benzene poisoning risk could be higher. There was no clear relation between the DNA repair capacity on chromosome level and the benzene poisoning risk.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzeno
/
Dano ao DNA
/
Exposição Ocupacional
/
Reparo do DNA
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Wei Sheng Yan Jiu
Assunto da revista:
SAUDE PUBLICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China