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Early exposure to latex products mediates latex sensitization in spina bifida but not in other diseases with comparable latex exposure rates.
Eiwegger, T; Dehlink, E; Schwindt, J; Pomberger, G; Reider, N; Frigo, E; Rokitansky, A M; Urbanek, R; Szépfalusi, Z.
Afiliação
  • Eiwegger T; Department of Paediatrics, Medical University of Vienna, Vienna, Austria.
Clin Exp Allergy ; 36(10): 1242-6, 2006 Oct.
Article em En | MEDLINE | ID: mdl-17014431
BACKGROUND: The high prevalence of latex sensitization in patients with spina bifida (SB) has been attributed to repeated and early exposure to latex products. Other diseases such as gastroschisis/omphalocoele and post-haemorrhagic/congenital hydrocephalus are also associated with repeated and early latex exposure. OBJECTIVE: The aim of the study was to evaluate whether the high prevalence of latex sensitization in patients with SB is rather related to the underlying disease itself than to disease-associated known risk factors. METHODS: We compared children with SB (n=35), children with gastroschisis/omphalocoele (G/O, n=20) and children with post-haemorrhagic/congenital hydrocephalus (PH, n=45). All children with SB and PH had a ventriculo-peritoneal shunt since a very young age. Patients who underwent three or less surgical procedures matched in terms of age, number of operations, atopy and gender distribution, and were analysed for IgE sensitization rates to latex. RESULTS: In the SB group, 16 of 35 patients (46%) showed elevated latex-specific IgE antibodies in contrast to one of 20 patients (5%) in the G/O group and four of 45 patients (8.9%) in the PH group (P<0.0005 and P<0.005, Fisher's exact test). Comparing matched control groups (
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disrafismo Espinal / Hipersensibilidade ao Látex Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Exp Allergy Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Áustria País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disrafismo Espinal / Hipersensibilidade ao Látex Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Exp Allergy Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Áustria País de publicação: Reino Unido