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Cerebrospinal fluid thyrotropin-releasing hormone concentrations in alcoholics and normal controls.
Roy, A; Bissette, G; Nemeroff, C B; DeJong, J; Ravitz, B; Adinoff, B; Linnoila, M.
Afiliação
  • Roy A; Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
Biol Psychiatry ; 28(9): 767-72, 1990 Nov 01.
Article em En | MEDLINE | ID: mdl-1701664
Alterations in hypothalamic-pituitary-thyroid axis function have been reported in alcoholism. Blunting of the thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) occurs in approximately 25% of alcoholic patients. Using a sensitive radioimmunoassay that allows TRH itself to be measured in cerebrospinal fluid (CSF), CSF concentrations of TRH were measured in alcoholics and normal controls. There was no significant difference in TRH concentrations between the groups. However, among the controls there was a significant correlation between CSF concentrations of the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and CSF concentrations of TRH. This correlation was lacking in the alcoholics. These findings are of interest because basic neurobiological studies have reported that TRH and serotonin are co-localized in certain neurons in the rat central nervous system.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Liberador de Tireotropina / Alcoolismo Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biol Psychiatry Ano de publicação: 1990 Tipo de documento: Article País de publicação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hormônio Liberador de Tireotropina / Alcoolismo Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biol Psychiatry Ano de publicação: 1990 Tipo de documento: Article País de publicação: Estados Unidos