Principal component, Varimax rotation and cost analysis of volume effects in rectal bleeding in patients treated with 3D-CRT for prostate cancer.
Phys Med Biol
; 51(20): 5105-23, 2006 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-17019028
ABSTRACT
We investigate the utility of principal component analysis as a tool for obtaining dose-volume combinations related to rectal bleeding after radiotherapy for prostate cancer. A direct implementation of principal component analysis reduces the number of degrees of freedom from the patient's dose-volume histograms that are associated with bleeding. However, when low-variance principal components are strongly correlated to outcome, their interpretation is problematic. A Varimax rotation is employed to aid in interpretability of the low-variance principal components. This procedure brings us closer to finding unique dose-volume combinations related to outcome but reintroduces correlation, requiring analysis of the overlap of information contained in such modes. Finally, we present examples of cost-benefit analyses for candidate dose-volume constraints for use in treatment planning.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Lesões por Radiação
/
Planejamento da Radioterapia Assistida por Computador
/
Medição de Risco
/
Radioterapia Conformacional
/
Hemorragia Gastrointestinal
Tipo de estudo:
Etiology_studies
/
Health_economic_evaluation
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Phys Med Biol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos