The Baylis-Hillman approach to quinoline derivatives.

Familoni, Oluwole B; Klaas, Phindile J; Lobb, Kevin A; Pakade, Vusumzi E; Kaye, Perry T

Familoni, Oluwole B; Klaas, Phindile J; Lobb, Kevin A; Pakade, Vusumzi E; Kaye, Perry T.

Afiliação

Familoni OB; Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa.

Org Biomol Chem ; 4(21): 3960-5, 2006 Nov 07.

Article em En | MEDLINE | ID: mdl-17047876

ABSTRACT

ABSTRACT

Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.

Assuntos

Modelos Químicos; Quinolinas/química; Quinolinas/síntese química

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Modelos Químicos Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: África do Sul

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