Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: a case study of intravenously administered propofol.
J Nanosci Nanotechnol
; 6(9-10): 3017-24, 2006.
Article
em En
| MEDLINE
| ID: mdl-17048513
ABSTRACT
Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Propofol
/
Nanoestruturas
/
Cristais Líquidos
/
Lipídeos
/
Lipossomos
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
J Nanosci Nanotechnol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Suécia