[Cushing's syndrome. II. New forms of treatment]. / Syndroom van Cushing. II. Nieuwe behandelingen.
Ned Tijdschr Geneeskd
; 150(43): 2365-9, 2006 Oct 28.
Article
em Nl
| MEDLINE
| ID: mdl-17100127
ABSTRACT
Several new therapeutic options both medicinal and surgical, have emerged for the treatment of Cushing's syndrome. In Cushing's disease caused by an adrenocorticotropin (ACTH) secreting pituitary adenoma, the introduction ofendoscopic pituitary surgery offers better visualization of the sella than does the traditional explorative surgery. However, at present it is unclear whether this will result in a better outcome. New drugs under investigation include universal somatostatin analogues such as SOM230, and a combination of a somatostatin analogue and dopamine agonist known as dopastatin. These agents may also be effective for the medicinal treatment of ectopic ACTH-secretion. Treatment with radioactive-labelled somatostatin-analogues such as 177lutetium octreotate is another option for these patients. The primary treatment for ACTH-independent Cushing's syndrome is laparoscopic adrenalectomy. In rare cases of bilateral adrenal hyperplasia, medicinal treatment aimed at new regulatory pathways of cortisol secretion can be applied.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenoma
/
Síndrome de Cushing
/
Adenoma Hipofisário Secretor de ACT
Limite:
Humans
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
2006
Tipo de documento:
Article