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Effect of living donor liver transplantation on outcome of children with inherited liver disease and hepatocellular carcinoma.
Ozçay, Figen; Canan, Oguz; Bilezikçi, Banu; Torgay, Adnan; Karakayali, Hamdi; Haberal, Mehmet.
Afiliação
  • Ozçay F; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Baskent University Faculty of Medicine, Ankara, Turkey. fozcay@yahoo.com
Clin Transplant ; 20(6): 776-82, 2006.
Article em En | MEDLINE | ID: mdl-17100729
We described six children with heritable liver disease and hepatocellular carcinoma treated with living-related liver transplantation. Underlying liver diseases were type-1 tyrosinemia (three patients), progressive familial intrahepatic cholestasis type II (two patients), and Wilson's disease (one patient). Two of the tumors were found incidentally during liver transplantation. Number of nodules was 12, 15, 3, 2, and 1 (in two patients). Three patients were treated with chemotherapy before the procedure. Chemotherapy was not given to any patient after liver transplantation. The mean follow-up was 17.7 +/- 6 months (range: 7-24). All patients are tumor recurrence free. Both graft and patient survival rates are 100% at a median of 18.5 months follow-up. Physicians in charge of treating children with heritable liver disease should screen them periodically for the development of hepatocellular carcinoma. Liver transplantation may offer these children better survival rates.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colestase Intra-Hepática / Transplante de Fígado / Carcinoma Hepatocelular / Doadores Vivos / Tirosinemias / Degeneração Hepatolenticular / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Transplant Assunto da revista: TRANSPLANTE Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Turquia País de publicação: Dinamarca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colestase Intra-Hepática / Transplante de Fígado / Carcinoma Hepatocelular / Doadores Vivos / Tirosinemias / Degeneração Hepatolenticular / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Transplant Assunto da revista: TRANSPLANTE Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Turquia País de publicação: Dinamarca