Biochemical and histological findings on the effect of fibronectin in rabbits with experimental corneal disorders.

Hiraki, S; Hayami, H; Numata, K; Kubota, Y; Kobayashi, M; Tanaka, S; Karges, H E

Hiraki, S; Hayami, H; Numata, K; Kubota, Y; Kobayashi, M; Tanaka, S; Karges, H E.

Afiliação

Hiraki S; Department of Ophthalmology, School of Medicine, Toyama Medical and Pharmaceutical University, Japan.

Arzneimittelforschung ; 40(12): 1336-40, 1990 Dec.

Article em En | MEDLINE | ID: mdl-1710125

ABSTRACT

ABSTRACT

The effects of purified plasma fibronectin (FN) in corneal disorders were investigated. Histological findings, the levels of ascorbic acid (AA) and glutathione (GSH) in tear fluids were observed sequentially in rabbits with experimental corneal damage and the degree of corneal lesions was observed. The results indicated that healing of the tissue damage was more promoted in the FN group than in the controls and it was suggested that FN promoted the healing of corneal disorders.

Assuntos

Doenças da Córnea/tratamento farmacológico; Fibronectinas/uso terapêutico; Animais; Ácido Ascórbico/metabolismo; Cromatografia Líquida de Alta Pressão; Córnea/patologia; Doenças da Córnea/patologia; Glutationa/metabolismo; Microscopia Eletrônica; Coelhos; Coloração e Rotulagem; Lágrimas/metabolismo

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibronectinas / Doenças da Córnea Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Arzneimittelforschung Ano de publicação: 1990 Tipo de documento: Article País de afiliação: Japão País de publicação: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY

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