Tachykinins mediate changes in spinal reflexes after activation of unmyelinated muscle afferents in the rat.
Acta Physiol Scand
; 141(1): 57-61, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-1711267
ABSTRACT
The effect of intrathecally applied tachykinin antagonist D-NicLys1, 3-Pal3, D-Cl2Phe5, Asn6, D-Trp7.9, Nle11-substance P, spantide II, on the long-term increase of spinal cord excitability after activation of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanaesthetized rats. A conditioning stimulus train (1 Hz, 20 s) that activated unmyelinated fibres in the gastrocnemius muscle nerve facilitated the flexor reflex for about 1 h, which was strongly blocked by pretreatment with spantide II (3 micrograms). The present results indicate that the facilitation of the flexor reflex by conditioning stimulation of a muscle nerve is mediated by tachykinins and possibly other neuropeptides which may be released from the central terminals of these unmyelinated afferents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reflexo
/
Nervos Espinhais
/
Taquicininas
/
Músculos
/
Neurônios Aferentes
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Scand
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Suécia